Leading longevity NADH formula

Nicotinic acid from food and supplements is converted in the body into its main metabolically active form nicotinamide adenine dinucleotide (NAD).

NAD has two main forms - NAD+ (known as the oxidized state) and NADH (known as the reduced state). NAD in both forms plays a major role in the citric acid cycle and the electron transport chain, key steps in respiration that occur in the mitochondria of each cell (known as the powerhouse of the cell). It’s through this process that the body obtains the energy it needs to function (in the form of ATP).

NAD+ is also used by specialist proteins in the cells known as sirtuins which in turn, play an important role in various biochemical processes and cell functions. 

NAD is produced in the body in various different ways. It can be produced either from l-tryptophan (via the De novo synthesis pathway) or from vitamin B3 (nicotinamide or nicotinic acid, via the Preiss handler pathway).

Natural NAD production declines as we age as these production pathways become less efficient.

B vitamins such as B3 (niacin) are water soluble and as such, can absorb quite quickly in the gut. Water-soluble nutrients may also be lost by diuretics such as caffeine, alcohol and diuretic medications as they increase the amount of water that leaves the body. A slow release formulation allows the compounds to absorb slowly into the blood-stream allowing a steady release and preventing excessive losses.