Quality is key in Q10 supplements

Q10 Pharma Nord

Q10 and its link to health

CoQ10 is a naturally occurring vitamin-like substance that plays a key role in supplying the body with its energy requirements. CoQ10 is required by the body for the normal functioning of all tissues and those with the highest energy requirements (heart and muscles) are particularly reliant on an adequate supply. It is also important as a cell membrane protecting antioxidant. Co-enzyme Q10 is found naturally in all the cells of the human body, where it supports the energy metabolism. We are able to produce this in our liver, and we get a certain amount from the food we eat, or indeed you can take a supplement. As people age, the body's capacity to produce its own CoQ10 is reduced, levels peak in the 20's and gradually decrease from that point onwards. CoQ10 levels are also depleted by intense exercise, statin use or chronic disease hence the rationale for CoQ10 supplementation.

Supported by research
Bio-Quinone Q10 was selected for use by both the KiSel 10 Study and the Q-Symbio Study due to its quality and bioavailability. Pharma Nord launched Bio-Quinone Q10 more than 25 years ago; right from the beginning, they worked hard to develop a formula that could ensure the highest level of bio-availability of the active compound. Today, more than 100 published studies document the superior absorption, safety, and effect.

The importance of bioavailability
Bioavailability is defined as the proportion of an ingested substance that is absorbed from the digestive tract into the bloodstream. For the impact of CoQ10 to be felt, the bio-availability of the supplement is fundamental. To have an impact the coenzyme must be effectively absorbed and used by the body, raising blood Q10 levels to a sufficient level. The only objective measure of bioavailability comes from data obtained in clinical studies of human subjects, as documented in the medical literature. CoQ10 when first supplied is in the form of orange crystals, which cannot be absorbed from the digestive tract. A patented method is then used to disperse the CoQ10 crystals into single molecules, which can then be absorbed. Because CoQ10 is a lipid soluble substance, the crystals are dispersed in a carrier oil, as this aids absorption. However there is a common misconception that mixing CoQ10 with a carrier oil is sufficient to facilitate absorption; as noted above the crystals must first be dispersed, and equally importantly must not reform during the product shelf-life. It should also be noted that CoQ10 in its naturally occurring form cannot be made more water soluble- any structural modification means the molecule is no longer CoQ10.

Q10 Absorbtion Graph

Quality is important
Consumers may not be aware of the research or studies behind Q10 and can easily end up buying inexpensive, low quality Q10 supplements that look perfect but are actually a complete waste of money. In fact, if a manufacturer does not know how to handle the Q10 raw material properly during the manufacturing process, the Q10 will form insoluble lumps (or crystals) that are unable to pass through the intestinal barrier and enter the blood.

Oxidised and reduced forms of CoQ10
CoQ10 occurs in the body in two forms, oxidised (ubiquinone) and reduced (ubiquinol). These forms undergo continual inter-conversion as part of the normal functioning of CoQ10, and neither form is more important than the other. Most people are able to sufficiently absorb CoQ10 in its oxidised (ubiquinone) form, and this is the form on which most randomised controlled clinical trial studies have been based. In this regard, there have been more than 90 clinical trial studies that have used Bio-Quinone CoQ10, confirming the bioavailability, efficacy and safety of this product. Supplementation with the reduced (ubiquinol) form of CoQ10 may be beneficial in people with impaired digestive absorption, for example those with irritable bowel syndrome or the elderly. Relatively few clinical trials have been carried out to date using the ubiquinol form of CoQ10. It should be noted that ubiquinol is extremely sensitive to the effect of air and light. Some products claiming to contain ubiquinol in fact contain ubiquinone – this can be determined by cutting open the capsule; ubiquinol should be white in colour whereas ubiqinone is yellow.

Visit www.q10.co.uk / www.q-symbio.com / www.kisel-10.co.uk for more information.

Further reading:

Alehagan U et al (2013) Cardiovascular mortality and N-terminal proBNP reduced after combined selenium and CoQ10 supplementation: a 5 year prospective randomised double blind placebo controlled trial among elderly Swedish citizens. Int J Cardiol; 167:1860-1866.
Alehagan U et al (2015a) Levels of sP-selectin and hs-CRP decrease with dietary intervention with selenium and CoQ10. PLOS ONE; 10:e0137680
Alehagan U et al (2015b) Less increase of copeptin and MR-proADM due to intervention with selenium and CoQ10 for 4 years- follow up results of a randomised controlled trial in elderly citizens. Biofactors; 41: 443-452.
Alehagan U et al (2015c) Reduced cardiovascular mortality 10 years after supplementaion with selenium and CoQ10 for 4 years: follow up results of a randomised controlled trial in elderly citizens. PLOS One; 10: e0141641
Alehagan U et al (2016) Supplementation with selenium and CoQ10 reduces cardiovascular mortality in elderly with low selenium status. PLOS ONE; 11:e0157541.
Johansson P et al (2013) Effect of selenium and CoQ10 on the cardiac biomarker NT-proBNP. Scand Cardiovadc J; 1-8.
Johansson P et al (2015) Improved health related quality of life and more days out of hospital with supplementation with selenium and CoQ10 combined. J Nutr Health Aging; 19: 870-877.
Mantle D (2015) CoQ10 and cardiovascular disease: an overview. Br J Cardiol; 22:160-166
Okuyama H et al (2015) Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms. Expert Rev Clin Pharmacol; 8: 189-199.

December 2016